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The Human Genome Project has set the stage for countless advancements in our understanding of human DNA and its role in the diagnosis of disease. Nowhere is this truer than in the area of women's health. Pathologists and clinicians are increasingly turning to the power of molecular genetics for early and accurate diagnoses of disease.

New testing methods are creating opportunities to screen for common disorders affecting women, such as Human papillomavirus (HPV), Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), Cystic Fibrosis (CF), Herpes Simplex Virus I & II and Inherited Thrombophilia (IHT). These innovations offer pathologists and clinicians the ability to add molecular diagnostics to their laboratories.

The Advantages of Molecular Diagnostics
DNA can be reliably extracted from a variety of sources, including blood, tissue, or cells from a liquid Pap test, to produce a sample that can be screened for disease. Using molecular diagnostics, physicians can diagnose diseases earlier, or even before they occur. Molecular testing offers superior sensitivity and specificity, as well as added diagnostic utility when combined with cytology results.

PCR: The Gold Standard for Molecular Testing
Polymerase Chain Reaction (PCR) is the most broadly applicable method used in gene-based testing. The basis of PCR is the use of an enzyme to amplify specific parts of a gene, thereby mimicking what occurs in vivo during DNA synthesis.

The benefits of PCR include increased flexibility, sensitivity, specificity and reliability.PCR provides appropriate clinical sensitivity by amplifying small amounts DNA to pick up minute disease signals, allowing for efficient interpretation of DNA mutations. At the same time, PCR's specificity pinpoints a particular disease at the exact location of the change in the DNA sequence.

In just a few hours, PCR-based testing gives pathologists and clinicians the ability to screen for a host of disorders efficiently and accurately with superior analytic performance. PCR allows pathologists to perform a large number of tests, scalable to the market, and offers proven technology for reimbursable clinical laboratory testing.

The Benefits of West Coast PAP in Women's Health
West Coast PAP with PCR is more then just a series of tests; it is a strategy for success in women's health. West Coast PAP allows our pathologist to screen for Human papillomavirus (HPV), Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), Cystic Fibrosis (CF), Herpes Simplex Virus I & II and Inherited Thrombophilia (IHT) from a single collection.

West Coast PAP identifies 40 HPV types. West Coast PAP detects an additional seven HPV types classified as high-risk when compared to the Hybrid Capture® 2 method, providing better correlation to cytology diagnoses and accurate triage management for patients referred on to colposcopy. HPV genotyping enables our pathologists to more accurately predict the outcome of HPV infections and to monitor mixed or multiple, persistent and re-infections by genotype.



Molecular Diagnostics - HPV Typing, CTNG, CF, IHT, HSV

The conventional Pap test only indicates the possibility of cervical cancer. The Liquid Based Pap can be used for a more direct diagnosis when tested through a molecular diagnostic system like West Coast PAP.



Our Services In Molecular DNA and Women's Health

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